{{#if first_name}}Hi, {{capitalizeFirst (lower first_name)}}.{{else}}Hi.{{/if}} By the time a startup gets to the Series B stage, it’s typically shown some scale and traction. In other words, investors are no longer placing bets on unproven ideas. A review of our Series B funding data shows that investors are finding plenty to like in the current cohort of companies, with startups in a surprisingly diverse array of areas — from robotics to biotech — receiving Series B rounds, even as the median check size has hit a new high. Plus, a trio of $500 million-plus funding deals to startups in space tech and AI infrastructure led our weekly Top 10 list.

👀 The Series B pipeline looks refreshingly diversified

Overall Series B funding levels have steadily rebounded after hitting a low in 2023, and startups securing the largest rounds at this stage run the gamut from biotech to robotics to security, a review of our data shows. And while AI is a leading theme, the pipeline of funded Series B companies is anything but cookie-cutter.

Related Crunchbase lists:
• Series B Funding To US Startups
• Largest US Series B Rounds Of Past Six Months

🏆 Top 10: Space tech and AI startups raise half-billion-dollar rounds

Last week was a relatively brisk one for large startup funding rounds, led by three deals of $500 million or more in the space tech and AI infrastructure sectors, Crunchbase data shows. We also saw some good-sized deals around healthcare, neuroscience and enterprise software.

See also: The Crunchbase Megadeals Board

🎤 Tim Draper on AI, bitcoin and building ‘human accelerators’

In a recent interview with Crunchbase News, longtime startup investor Tim Draper discusses what’s occupying his time now — from expanding “Meet the Drapers” to experimenting with AI-powered digital twins that interact with founders and evaluate pitch decks. He also shares his view on how the current AI cycle resembles past tech booms, and his philosophy on regulation.

☣️ Intersection of biosecurity and AI sees seed-stage spike

As AI capabilities advance, some investors are turning their attention to a darker frontier: biosecurity. Startups including Valthos and Red Queen Bio have raised tens of millions of dollars in initial funding to build AI systems designed to detect and counter biological threats, with OpenAI among their backers, Crunchbase data shows. While the capital committed so far is tiny relative to the broader AI boom, the mission is ambitious: to ensure defenses scale as quickly as the risks in a world where biology, like AI, evolves at breakneck speed.

🔎 Exclusive: YC-backed Denki gets $4.1M to automate financial audits

Denki, a startup that has built AI-powered software for financial auditors at public companies, told Crunchbase News exclusively about its $4.1 million in new funding. The San Francisco-based startup was founded last year by two brothers, now both in their 20s. It aims to make financial audits — traditionally heavily manual and tedious — run more like software code.

Related Crunchbase list: Financial Services Global Funding 2025

Recent Investments

	Sierra Space $550M / Series C
Sierra Space is a commercial space company that specializes in the development of advanced space technologies and solutions.
Categories: Advanced Materials • Aerospace • Industrial Manufacturing • Space Travel • Transportation
Founders: Eren Ozmen, Fatih Ozmen
Investors: LuminArx Capital Management LP (Lead), Andalusian Private Capital, Coatue + 2 more
	Science $230M / Series C
Science is a clinical-stage medical technology company that develops neuroengineering systems to address neurological and sensory disorders.
Categories: Biotechnology • Medical • Neuroscience
Founders: Alan Mardinly, Max Hodak
Investors: Khosla Ventures (Lead), Lightspeed Venture Partners (Lead), IQT + 3 more
	Cognito Therapeutics $105M / Series C
Cognito Therapeutics develops neurotechnology therapies to treat neurodegenerative diseases by stimulating specific brain activity patterns.
Categories: Biotechnology • Health Diagnostics • Medical Device • Neuroscience • Therapeutics
Founders: Li-Huei Tsai
Investors: IAG Capital Partners (Lead), Morningside (Lead), Starbloom Capital (Lead) + 3 more

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Amedeo Air Four Plus Pending acquisition by Lesha Bank for $1.0B

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